MYELODYSPLASTIC SYNDROMES

Introduction: Myelodysplastic syndrome is a pathology characterized by its hematopoietic, pluripotential ineffective process in the bone marrow, i.e. causing dysplasia at least one of hematopoietic lines with functional and morphological alterations, which, some point may evolve into leukemia. Objective: review, analyze describe most notable features myelodysplastic syndromes. Methodology: A total 20 articles were analyzed this including review original articles, as well clinical cases, which 11 bibliographies used because other not relevant to study. The sources information PubMed, SciELO, Google Scholar, Medigraphic Cochrane; terms search for Spanish, Portuguese English were: syndrome, anemia, Results: It estimated have an incidence 4-12 conditions out 100 000 patients per year, it can reach up 30 individuals older than 70 years age. occurrence anomaly pediatric age young adults rare infrequent, certain predominance male sex has been reported, ratio 1:5, no relationship race found. Most develop symptomatology related cytopenias anemia; isolated neutropenias thrombocytopenias also occur, although less frequently. Conclusions: syndromes are highly complex disorders low incidence. They mainly affect production stem cells, being difficult approach, due mutation affection that these entail, triggering aggressive dysplastic blood diseases such anemias leukemias, makes therapeutic decisions difficult, so extremely important make correct diagnosis based on clinical, exclusion analysis. In addition, condition must be taken account, treatment effective survival adequate. Keywords:MDS:Myelodysplastic syndrome.